جاري التحميل...
جاري تحميل محتوى الصفحةجاري التحميل...
جاري تحميل محتوى الصفحة
conviban 100mg 20 scored f.c. tabs
about topiramate a sulfamate-substituted monosaccharide carbonic anhydrase inhibitor anticonvulsant antimigraine. mechanism of action of topiramate topiramate acts on the motor cortex where it stabilizes neuronal membrane and inhibits the spread of seizur
Drug Monograph — topiramate
echanism of Action The precise mechanisms by which topiramate exerts its anticonvulsant and preventive migraine effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and the preventive treatment of migraine. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV.
هذه المعلومات الدوائية مُستخلصة من مصادر طبية موثوقة (FDA/Altibbi) وهي للتثقيف الصحي العام فقط، ولا تُغني عن استشارة الصيدلي أو الطبيب المختص. لا تبدأ أو توقف أو تغيّر جرعة أي دواء بدون إشراف طبي.