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lipanthyl supra 160mg 30 tablets
خافض للكوليسترول والدهون
Drug Monograph — fenofibrate
echanism of Action The active moiety of fenofibrate is fenofibric acid. The pharmacological effects of fenofibric acid in both animals and humans have been extensively studied through oral administration of fenofibrate. The lipid-modifying effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor α (PPARα). Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). The resulting decrease in TG produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Activation of PPARα also induces an increase in the synthesis of apolipoproteins A-I, A-II and HDL-cholesterol. Fenofibrate also reduces serum uric acid levels in hyperuricemic and normal individuals by increasing the urinary excretion of uric acid.
هذه المعلومات الدوائية مُستخلصة من مصادر طبية موثوقة (FDA/Altibbi) وهي للتثقيف الصحي العام فقط، ولا تُغني عن استشارة الصيدلي أو الطبيب المختص. لا تبدأ أو توقف أو تغيّر جرعة أي دواء بدون إشراف طبي.

LIPITOR 10 MG 28 TABS.
ATORVASTATIN
ZETACOLEST 180 MG 30 F.C. TABS.
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atrozemb 10/10mg 30 f.c. tab
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atrozemb 20/10mg 30 f.c. tab
atorvastatin+ezetimibe